abnormal blood–brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by mri

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ID: 167179
2014
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Abstract
Objectives: To investigate whether blood–brain barrier (BBB) permeability is disrupted in normal appearing white matter in MS patients, when compared to healthy controls and whether it is correlated with MS clinical characteristics. Methods: Dynamic contrast-enhanced MRI was used to measure BBB permeability in 27 patients with MS and compared to 24 matched healthy controls. Results: Permeability measured as Ktrans was significantly higher in periventricular normal appearing white matter (NAWM) and thalamic gray matter in MS patients when compared to healthy controls, with periventricular NAWM showing the most pronounced difference. Recent relapse coincided with significantly higher permeability in periventricular NAWM, thalamic gray matter, and MS lesions. Immunomodulatory treatment and recent relapse were significant predictors of permeability in MS lesions and periventricular NAWM. Our results suggest that after an MS relapse permeability gradually decreases, possibly an effect of immunomodulatory treatment. Conclusions: Our results emphasize the importance of BBB pathology in MS, which we find to be most prominent in the periventricular NAWM, an area prone to development of MS lesions. Both the facts that recent relapse appears to cause widespread BBB disruption and that immunomodulatory treatment seems to attenuate this effect indicate that BBB permeability is intricately linked to the presence of MS relapse activity. This may reveal further insights into the pathophysiology of MS.
Reference Key
cramer2014neuroimage:abnormal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;S.P. Cramer;H. Simonsen;J.L. Frederiksen;E. Rostrup;H.B.W. Larsson
Journal chemical engineering journal
Year 2014
DOI
10.1016/j.nicl.2013.12.001
URL
http://www.sciencedirect.com/science/article/pii/S2213158213001605
Keywords
MRI blood–brain barrier perfusion mri diseases of the nervous system medical informaticsneurology multiple sclerosiscomputer applications to medicine

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