desenvolvimento e caracterização de nanocápsulas de poli (l-lactídeo) contendo benzocaína development and characterization of poli (l-lactide) nanocapsules containing benzocaine

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ID: 167143
2010
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Abstract
In this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of -38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment.
Reference Key
melo2010qumicadesenvolvimento Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Nathalie Ferreira Silva de Melo;Renato Grillo;André Henrique Rosa;Leonardo Fernandes Fraceto;Newton Luiz Dias Filho;Eneida de Paula;Daniele Ribeiro de Araújo
Journal greece and rome
Year 2010
DOI
10.1590/S0100-40422010000100013
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100013
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