effect of antihypertensive agents on stellate cells during liver regeneration in rats efeito de agentes anti-hipertensivos sobre as células estreladas durante a regeneração hepática em ratos

Clicks: 260
ID: 166928
2003
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Abstract
BACKGROUND: Although most studies have focused on the hepatocytes, all the hepatic cells participate in the regenerative process, among them the stellate cells. The stellate cells are mesenchymal cells involved in local neurotransmission and paracrine regulation of several liver functions. Acute hepatic tissue loss promotes the proliferation and activation of stellate cells from a quiescent state to myofibroblast-like cells. AIM: Investigate the effects of antihypertensive agents on the stellate cell population during the liver regenerative phenomenon in rats. METHODS: Adult male Wistar rats received lisinopril, losartan, bradykinin, or saline solution in a proportional volume, intraperitoneally, before and after 70% partial hepatectomy. Animals from the experimental and saline groups were sacrificed at 36 hours after partial hepatectomy. The alpha-smooth muscle actin labelled stellate cells population was counted in the periportal and pericentral zones of the liver specimen. RESULTS: The labelled stellate cells were more numerous in the control group both in the periportal and pericentral zones at 36 hours after partial hepatectomy than at the other times. The population of stellate cells was significantly lower in the losartan group and higher in the bradykinin and lisinopril groups than in the control group. CONCLUSIONS: These results suggest that losartan can inhibit and bradykinin and lisinopril can stimulate the stellate cell population during liver regeneration in rats. These cells synthesize several substances to stimulate liver regeneration.
RACIONAL: Embora a maioria dos estudos focalize os hepatócitos, todas as células hepáticas participam do processo regenerativo, entre elas as células estreladas, que são células mesenquimais envolvidas na regulação de uma série de funções hepáticas. A perda aguda de parênquima hepático induz proliferação e ativação destas células, a partir de estado de quiescência para fenótipo semelhante a miofibroblastos. OBJETIVO: Investigar o efeito de agentes anti-hipertensivos sobre a população de células estreladas durante o fenômeno regenerativo hepático em ratos. MÉTODOS: Ratos machos Wistar receberam lisinopril, losartan, bradicinina ou solução salina, via intraperitonial, antes e após a hepatectomia parcial a 70%. Animais pertencentes aos grupos experimental e controle foram sacrificados 36 horas após a cirurgia. A população de células estreladas marcadas para a a-actina de músculo liso foi estimada nas zonas periportal e pericentral das amostras hepáticas. RESULTADOS: No grupo controle, observou-se maior número de células estreladas ativadas 36 horas após a hepatectomia parcial. A população de células estreladas foi menor no grupo tratado com losartan e maior nos grupos tratados com bradicinina e lisinopril em relação ao grupo-controle. CONCLUSÃO: Estes resultados sugerem que o losartan pode inibir e a bradicinina e o lisinopril podem estimular a população de células estreladas durante a regeneração hepática em ratos. As células estreladas sintetizam importantes fatores de crescimento capazes de estimular a regeneração hepática.
Reference Key
ramalho2003arquivoseffect Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Leandra N. Z. Ramalho;Sérgio Zucoloto;Fernando S. Ramalho;Orlando de Castro-e-Silva Jr.;Fernando M. A. Corrêa
Journal journal of heterocyclic chemistry
Year 2003
DOI
10.1590/S0004-28032003000100009
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032003000100009
Keywords
antihypertensive agents liver regeneration Gastroenterology

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