high glucose induces n-linked glycosylation-mediated functional upregulation and overexpression of cav3.2 t-type calcium channels in neuroendocrine-like differentiated human prostate cancer cells

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ID: 166796
2017
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Abstract
Given that Cav3.2 T-type Ca2+ channels were functionally regulated by asparagine (N)-linked glycosylation, we examined effects of high glucose on the function of Cav3.2, known to regulate secretory function, in neuroendocrine-like differentiated prostate cancer LNCaP cells. High glucose accelerated the increased channel function and overexpression of Cav3.2 during neuroendocrine differentiation, the former prevented by enzymatic inhibition of N-glycosylation and cleavage of N-glycans. Hyperglycemia thus appears to induce N-linked glycosylation-mediated functional upregulation and overexpression of Cav3.2 in neuroendocrine-like differentiated prostate cancer cells.
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fukami2017journalhigh Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kazuki Fukami, Erina Asano, Mai Ueda, Fumiko Sekiguchi, Shigeru Yoshida, Atsufumi Kawabata
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Journal plant direct
Year 2017
DOI
10.1016/j.jphs.2016.12.004
URL
http://www.sciencedirect.com/science/article/pii/S1347861316301736
Keywords
prostate cancer pharmacology

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