novel stimulation paradigms with temporally-varying parameters to reduce synchronous activity at the onset of high frequency stimulation in rat hippocampus

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ID: 166736
2017
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Abstract
Deep brain stimulation (DBS) has shown wide applications for treating various disorders in the central nervous system by using high frequency stimulation (HFS) sequences of electrical pulses. However, upon the onset of HFS sequences, the narrow pulses could induce synchronous firing of action potentials among large populations of neurons and cause a transient phase of “onset response” that is different from the subsequent steady state. To investigate the transient onset phase, the antidromically-evoked population spikes (APS) were used as an electrophysiological marker to evaluate the synchronous neuronal reactions to axonal HFS in the hippocampal CA1 region of anesthetized rats. New stimulation paradigms with time-varying intensity and frequency were developed to suppress the “onset responses”. Results show that HFS paradigms with ramp-up intensity at the onset phase could suppress large APS potentials. In addition, an intensity ramp with a slower ramp-up rate or with a higher pulse frequency had greater suppression on APS amplitudes. Therefore, to reach a desired pulse intensity rapidly, a stimulation paradigm combining elevated frequency and ramp-up intensity was used to shorten the transition phase of initial HFS without evoking large APS potentials. The results of the study provide important clues for certain transient side effects of DBS and for development of new adaptive stimulation paradigms.
Reference Key
cai2017frontiersnovel Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ziyan Cai;Zhouyan Feng;Zheshan Guo;Wenjie Zhou;Zhaoxiang Wang;Xuefeng Wei
Journal Journal of enzyme inhibition and medicinal chemistry
Year 2017
DOI
10.3389/fnins.2017.00563
URL
http://journal.frontiersin.org/article/10.3389/fnins.2017.00563/full
Keywords
neuropsychiatry biological psychiatry

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