synthesis of no-carrier-added 4-[18f]fluorophenol from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide
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ID: 166409
2011
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Abstract
4-[18F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[18F]fluorophenoxy moiety. In order to prepare 4-[18F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [18F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide and [18F]fluoride with subsequent deprotection is described, yielding n.c.a. [18F]fluorophenol in 34 to 36% radiochemical yield.
| Reference Key |
ross2011moleculessynthesis
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|---|---|
| Authors | ;Tobias L. Ross;Johannes Ermert;Heinz H. Coenen |
| Journal | Journal of ethnopharmacology |
| Year | 2011 |
| DOI |
10.3390/molecules16097621
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| URL | |
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