altered modular organization of functional connectivity networks in cirrhotic patients without overt hepatic encephalopathy

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ID: 166367
2014
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Abstract
Minimal hepatic encephalopathy (MHE) is associated with changes in functional connectivity. To investigate the patterns of modular changes of the functional connectivity in the progression of MHE, resting-state functional magnetic resonance imaging was acquired in 24 MHE patients, 31 cirrhotic patients without minimal hepatic encephalopathy (non-HE), and 38 healthy controls. Newman’s metric, the modularity Q value, was maximized and compared in three groups. Topological roles with the progression of MHE were illustrated by intra- and intermodular connectivity changes. Results showed that the Q value of MHE patients was significantly lower than that of controls P<0.01 rather than that of non-HE patients P>0.05, which was correlated with neuropsychological test scores rather than the ammonia level and Child-Pugh score. Less intrasubcortical connections and more isolated subcortical modules were found with the progression of MHE. The non-HE patients had the same numbers of connect nodes as controls and had more hubs compared with MHE patients and healthy controls. Our findings supported that both intra- and intermodular connectivity, especially those related to subcortical regions, were continuously impaired in cirrhotic patients. The adjustments of hubs and connector nodes in non-HE patients could be a compensation for the decreased modularity in their functional connectivity networks.
Reference Key
zheng2014biomedaltered Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gang Zheng, Liping Zhang, Long Jiang Zhang, Qiang Li, Zhiying Pan, Xue Liang, Donghong Shi, Guang Ming Lu
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Journal spectrochimica acta - part a: molecular and biomolecular spectroscopy
Year 2014
DOI
10.1155/2014/727452
URL
http://dx.doi.org/10.1155/2014/727452
Keywords
Medicine

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