clinical, radiologic, and endoscopic characteristics upon diagnosis of patients with prehepatic portal hypertension at the instituto nacional de pediatría from 2001 to 2011

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ID: 166127
2014
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Abstract
Background: Prehepatic portal hypertension in children can be asymptomatic for many years. Once diagnosed, the therapeutic measures (pharmacologic, endoscopic, and surgical) are conditioned by the specific characteristics of each patient. In Mexico, there are no recorded data on the incidence of the disease and patient characteristics. Aims: To determine the main clinical, radiologic, and endoscopic characteristics upon diagnosis of these patients at the Instituto Nacional de Pediatría within the time frame of January 2001 and December 2011. Methods: A cross-sectional, retrolective, descriptive, and observational study was conducted in which all the medical records of the patients with portal hypertension diagnosis were reviewed. Results: There was a greater prevalence of prehepatic etiology (32/52) (61.5%) in the portal hypertension cases reviewed. Males (62.5%) predominated and 11 of the 32 patients were under 4 years of age. The primary reason for medical consultation was upper digestive tract bleeding with anemia (71.9%) and the main pathology was cavernomatous degeneration of the portal vein (65.6%). Splenoportography was carried out on 17 of the 32 patients. A total of 65.5% of the patients received the combination therapy of propranolol and a proton pump inhibitor. Initial endoscopy revealed esophageal varices in 96.9% of the patients, 12 of whom presented with gastroesophageal varices. Congestive gastropathy was found in 75% of the patients. The varices were ligated in 8 cases, sclerotherapy for esophageal varices was carried out in 5 cases (15.6%), and sclerotherapy for gastric varices was performed in 2 patients. Seventeen patients (53.1%) underwent portosystemic diversion: 10 of the procedures employed a mesocaval shunt and 7 a splenorenal shunt. Nine patients (28.1%) underwent total splenectomy. Conclusions: The primary cause of the disease was cavernomatous degeneration of the portal vein; it was predominant in males and the first symptom was variceal bleeding.
Reference Key
mondragn2014revistaclinical, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;F. Zárate Mondragón;J.O. Romero Trujillo;R. Cervantes Bustamante;M.A. Mora Tiscareño;E. Montijo Barrios;J.F. Cadena León;M. Cázares Méndez;E.M. Toro Monjaraz;J. Ramírez Mayans
Journal Molecular brain
Year 2014
DOI
10.1016/j.rgmxen.2014.11.005
URL
http://www.sciencedirect.com/science/article/pii/S2255534X14000978
Keywords
Children Gastroenterology méxicodiseases of the digestive system prehepatic portal hypertension

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