synthesis of n-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives for the treatment of metabolic syndrome
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2013
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Abstract
Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance.
| Reference Key |
deka2013internationalsynthesis
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| Authors | ;Nabajyoti Deka;Swapnil Bajare;Jessy Anthony;Amrutha Nair;Anagha Damre;Dharmeshkumar Patel;Chandrika B-Rao;H. Sivaramakrishnan;Shivaprakash Jagalur Mutt;Chandan Wilankar;Rosalind Marita |
| Journal | Journal of human genetics |
| Year | 2013 |
| DOI |
10.1155/2013/201580
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| URL | |
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