synthesis of n-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives for the treatment of metabolic syndrome

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2013
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Abstract
Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance.
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deka2013internationalsynthesis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nabajyoti Deka, Swapnil Bajare, Jessy Anthony, Amrutha Nair, Anagha Damre, Dharmeshkumar Patel, Chandrika B-Rao, H. Sivaramakrishnan, Shivaprakash Jagalur Mutt, Chandan Wilankar, Rosalind Marita
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Journal Journal of human genetics
Year 2013
DOI
10.1155/2013/201580
URL
http://dx.doi.org/10.1155/2013/201580
Keywords
therapeutics pharmacology

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