impact of population stratification on family-based association in an admixed population
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ID: 165683
2015
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Abstract
Population substructure is a well-known confounder in population-based case-control genetic studies, but its impact in family-based studies is unclear. We performed population substructure analysis using extended families of admixed population to evaluate power and Type I error in an association study framework. Our analysis shows that power was improved by 1.5% after principal components adjustment. Type I error was also reduced by 2.2% after adjusting for family substratification. The presence of population substructure was underscored by discriminant analysis, in which over 92% of individuals were correctly assigned to their actual family using only 100 principal components. This study demonstrates the importance of adjusting for population substructure in family-based studies of admixed populations.
| Reference Key |
mersha2015internationalimpact
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| Authors | ;T. B. Mersha;L. Ding;H. He;E. S. Alexander;X. Zhang;B. G. Kurowski;V. Pilipenko;L. Kottyan;L. J. Martin;D. W. Fardo |
| Journal | balıkesir medical journal |
| Year | 2015 |
| DOI |
10.1155/2015/501617
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