membranas de poli (ácido lático-co-ácido glicólico) como curativos para pele: degradação in vitro e in vivo poly (lactide-co-glycolide) membranes as skin repair: in vitro and in vivo degradation
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Abstract
Poly (lactide-co-glycolide) is a polymer with bioabsorption and biodegradation properties. The physical and chemical properties of this polymer have been studied in order to modulate its susceptibility to degradation and its interaction with cells and biological fluids, aiming at medical and dental applications. In this work, membranes of poly (lactide-co-glycolide) with and without plasticizer were prepared by solvent evaporation and characterized by in vitro and in vivo experiments. In vitro studies showed that the glass transition temperature decreased due to the addition of plasticizer and, consequently, their flexibility increased. During degradation, crystalline areas and porous appear. In vivo studies showed that the polymer degraded rapidly without causing inflammation and protected areas that were exposed to external agents. Furthermore, membranes improved wound healing time, indicating that they can be potentially used in skin repair.
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rezende2005polmerosmembranas
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| Journal | journal of the chemical society, perkin transactions 1 |
| Year | 2005 |
| DOI |
10.1590/S0104-14282005000300015
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| URL | |
| Keywords | Keywords not found |
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