intestinal epithelium in inflammatory bowel disease

Clicks: 248
ID: 165552
2014
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Abstract
The intestinal epithelium has a strategic position as a protective physical barrier to luminal microbiota and actively contributes to the mucosal immune system. This barrier is mainly formed by a monolayer of specialized intestinal epithelial cells (IECs) that are crucial in maintaining intestinal homeostasis. Therefore, dysregulation within the epithelial layer can increase intestinal permeability, lead to abnormalities in interactions between IECs and immune cells in underlying lamina propria, and disturb the intestinal immune homeostasis, all of which are linked to the clinical disease course of inflammatory bowel disease (IBD). Understanding the role of the intestinal epithelium in IBD pathogenesis might contribute to an improved knowledge of the inflammatory processes and the identification of potential therapeutic targets.
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ecoskun2014frontiersintestinal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Mehmet eCoskun
Journal Stroke
Year 2014
DOI
10.3389/fmed.2014.00024
URL
http://journal.frontiersin.org/Journal/10.3389/fmed.2014.00024/full
Keywords
crohn’s disease ulcerative colitis inflammatory bowel disease tight junctions intestinal epithelium

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