advanced cell culture techniques for cancer drug discovery

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ID: 165302
2014
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Abstract
Human cancer cell lines are an integral part of drug discovery practices. However, modeling the complexity of cancer utilizing these cell lines on standard plastic substrata, does not accurately represent the tumor microenvironment. Research into developing advanced tumor cell culture models in a three-dimensional (3D) architecture that more prescisely characterizes the disease state have been undertaken by a number of laboratories around the world. These 3D cell culture models are particularly beneficial for investigating mechanistic processes and drug resistance in tumor cells. In addition, a range of molecular mechanisms deconstructed by studying cancer cells in 3D models suggest that tumor cells cultured in two-dimensional monolayer conditions do not respond to cancer therapeutics/compounds in a similar manner. Recent studies have demonstrated the potential of utilizing 3D cell culture models in drug discovery programs; however, it is evident that further research is required for the development of more complex models that incorporate the majority of the cellular and physical properties of a tumor.
Reference Key
lovitt2014biologyadvanced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Carrie J. Lovitt;Todd B. Shelper;Vicky M. Avery
Journal Journal of microencapsulation
Year 2014
DOI
10.3390/biology3020345
URL
http://www.mdpi.com/2079-7737/3/2/345
Keywords
Drug resistance microenvironment 3d culture high-throughput screeningbiology (general)

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