efficient synthesis and anti-fungal activity of oleanolic acid oxime esters
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ID: 164583
2013
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Abstract
In order to develop potential glucosamine-6-phosphate synthase inhibitors and anti-fungal agents, twenty five oleanolic acid oxime esters were synthesized in an efficient way. The structures of the new compounds were confirmed by MS, HRMS, 1H-NMR and 13C-NMR. Preliminary studies based on means of the Elson-Morgan method indicated that many compounds exhibited some inhibitory activity of glucosamine-6-phosphate synthase (GlmS), and the original fungicidal activities results showed that some of the compounds exhibited good fungicidal activities towards Sclerotinia sclerotiorum (Lib.) de Bary, Rhizoctonia solani Kuhn and Botrytis cinerea Pers at the concentration of 50 µg/mL. These compounds would thus merit further study and development as antifungal agents.
| Reference Key |
liang2013moleculesefficient
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|---|---|
| Authors | ;Xiaomei Liang;Jianjun Zhang;Daoquan Wang;Wei Wang;Lifeng Duan;Minjie Zhou;Hanqing Zhao |
| Journal | Journal of ethnopharmacology |
| Year | 2013 |
| DOI |
10.3390/molecules18033615
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| URL | |
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