adiponectin concentration in the orbital fat of patients with graves' ophthalmopathy

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ID: 164495
2013
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Abstract
Uri Soiberman,1,2 Ran Levy,1,2 Igal Leibovitch1,2 1Department of Ophthalmology, Tel Aviv Medical Center, 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Background: "Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. Aim: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. Methods: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. Results: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). Conclusion: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups. Keywords: Graves' disease, Graves' orbitopathy, ELISA
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Authors Soiberman U, Levy R, Leibovitch I
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Journal e3s web of conferences
Year 2013
DOI
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http://www.dovepress.com/adiponectin-concentration-in-the-orbital-fat-of-patients-with-graves39-a14160
Keywords
ophthalmology

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