an interleukin-33/st2 signaling deficiency reduces overt pain-like behaviors in mice
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ID: 164336
2013
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Abstract
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present study asked whether IL-33/ST2 signaling is relevant to overt pain-like behaviors in mice. Acetic acid and phenyl-p-benzoquinone induced significant writhing responses in wild-type (WT) mice; this overt nociceptive behavior was reduced in ST2-deficient mice. In an antigen-challenge model, ST2-deficient immunized mice had reduced induced flinch and licking overt pain-like behaviors. In the formalin test, ST2-deficient mice also presented reduced flinch and licking responses, compared with WT mice. Naive WT and ST2-deficient mice presented similar responses in the rota-rod, hot plate, and electronic von Frey tests, indicating no impairment of motor function or alteration in basal nociceptive responses. The results demonstrate that IL-33/ST2 signaling is important in the development of overt pain-like behaviors.
| Reference Key |
magro2013brazilianan
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| Authors | ;D.A.C. Magro;M.S.N. Hohmann;S.S. Mizokami;T.M. Cunha;J.C. Alves-Filho;R. Casagrande;S.H. Ferreira;F.Y. Liew;F.Q. Cunha;W.A. Verri Jr |
| Journal | Free radical biology & medicine |
| Year | 2013 |
| DOI |
10.1590/1414-431X20132894
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| URL | |
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