in vitro effects of some botanicals with anti-inflammatory and antitoxic activity
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2016
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Abstract
Several extrinsic factors, like drugs and chemicals, can foster autoimmunity. Tetracyclines, in particular oxytetracycline (OTC), appear to correlate with the emergence of immune-mediated diseases. Accumulation of OTC, the elective drug for gastrointestinal and respiratory infectious disease treatment in broiler chickens, was reported in chicken edible tissues and could represent a potential risk for pets and humans that could assume this antibiotic as residue in meat or in meat-derived byproducts. We investigated the in vitro anti-inflammatory properties of a pool of thirteen botanicals as a part of a nutraceutical diet, with proven immunomodulatory activity. In addition, we evaluated the effect of such botanicals in contrasting the in vitro proinflammatory toxicity of OTC. Our results showed a significant reduction in interferon- (INF-) γ production by human and canine lymphocytes in presence of botanicals (p⁎<0.05). Increased INF-γ production, dependent on 24-hour OTC-incubation of T lymphocytes, was significantly reduced by the coincubation with Haematococcus pluvialis, with Glycine max, and with the mix of all botanicals (p⁎<0.05). In conclusion, the use of these botanicals was shown to be able to contrast OTC-toxicity and could represent a new approach for the development of functional foods useful to enhance the standard pharmacological treatment in infections as well as in preventing or reducing the emergence of inflammatory diseases.
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guidetti2016journalin
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| Authors | ;Gianandrea Guidetti;Alessandro Di Cerbo;Angela Giovazzino;Valentina Rubino;Anna Teresa Palatucci;Sara Centenaro;Elena Fraccaroli;Laura Cortese;Maria Grazia Bonomo;Giuseppina Ruggiero;Sergio Canello;Giuseppe Terrazzano |
| Journal | journal of photochemistry and photobiology b, biology |
| Year | 2016 |
| DOI |
10.1155/2016/5457010
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| URL | |
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