mechanism of oxidation of (p-substituted phenylthio)acetic acids with n-chlorosaccharin
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ID: 163741
2011
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Abstract
The kinetics of oxidation of (phenylthio)acetic acid (PTAA) with N-chlorosaccharin (NCSA) have been studied potentiometrically in 80:20 (v/v) acetonitrile-water medium at 298 K. The reaction is first-order each with respect to PTAA and NCSA and shows a negative dependence on [H+]. NCSA itself is shown to be the active oxidizing species. Effects of ionic strength variation, added saccharin, added acrylonitrile, added NaCl and solvent composition variation have been studied. Effect of substituents on the reaction rate has been analysed by employing various (p-sustituted phenylthio)acetic acids. The electron-releasing substituent in the phenyl ring of PTAA accelerates the reaction rate while the electron-withdrawing substituent retards the rate. The excellently linear Hammett plot yields a large negative ρ value, supporting the involvement a chlorosulphonium ion intermediate in the rate-determining step.
| Reference Key |
alhaj2011e-journalmechanism
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|---|---|
| Authors | ;N. M. I. Alhaj;A. M. Uduman Mohideen;S. Sofia Lawrence Mary |
| Journal | Journal of pharmaceutical and biomedical analysis |
| Year | 2011 |
| DOI |
10.1155/2011/342409
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