biochemical changes in pancytopenic and non pancytopenic dogs with ehrlichiosis/
alterações bioquímicas em cães citopênicos e não citopênicos com ehrlichiose

Clicks: 73
ID: 163490
2008
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Abstract
In order to study the biochemical changes in naturally infected dogs with Ehrlichia canis, blood samples from 57 animals were collected. Thirty-five healthy dogs were used as control group. Dosage of serum protein, albumin, globulin, albumin:globulin ratio (A:G), urea, creatinine, alanine aminotransferase (ALT) e alkaline phosphatase (AP) were carried out. The comparison of mean in infected and control group as well as the distribution of frequencies were investigated in order to associate the disease to the findings. Hypoproteinemia, hypoalbuminemia, decreased A:G ratio, hyperglobulinemia, and uremia were associated to ehrlichiosis (p < 0.05). Regarding pancytopenia, it was observed that ALT and creatinine were, respectively, the marker of ehrlichiosis in non pancytopenic (NP) and pancytopenic (P) dogs. There were no significantly differences in protein profile in NP and P dogs that support the presence of a marker for the disease.

Com o objetivo de estudar os parâmetros bioquímicos associados às funções renal e hepática em cães naturalmente infectados por Ehrlichia canis e associá-los à ehrlichiose, foram colhidas 57 amostras de sangue, com realização de dosagem de proteína plasmática total, albumina, globulina, relação albumina/ globulina (A/G), uréia, creatinina, alanino aminotransferase (ALT) e fosfatase alcalina (FA). Outros 35 cães em higidez foram utilizados como controle. Foram comparadas as médias dos animais infectados e controle, bem como a distribuição de freqüências, para associação dos resultados com a doença. Hipoproteinemia, hipoalbuminemia, redução da A/G, hiperglobulinemia e aumento de uréia estiveram associados à doença (p < 0,05). Foram comparados também os achados entre animais não pancitopênicos (NPan) e em pancitopenia (Pan), verificando-se que no primeiro grupo, houve aumento de ALT, e nos animais pancitopênicos, a creatinina foi o principal indicador de ehrlichiose. No caso do perfil protéico, não houve diferença que pudesse servir como marcador da fase da enfermidade nos animais infectados.

Reference Key
laposy2008semina:biochemical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Cecília Braga Laposy;Melina de Deus José;Vamilton Alvares Santarém
Journal frontiers in neuroendocrinology
Year 2008
DOI
10.5433/1679-0359.2008v29n4p845
URL
http://www.uel.br/revistas/uel/index.php/semagrarias/article/view/2719
Keywords
Agriculture (General)

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