brain structure and function in women with comorbid bipolar and premenstrual dysphoric disorder

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ID: 162895
2018
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Abstract
IntroductionHormonal fluctuations associated with female reproductive life events may precipitate or worsen affective episodes in women with bipolar disorder (BD). Previous studies have shown that women with BD report higher rates of premenstrual dysphoric disorder (PMDD) than controls. Further, bipolar women who report premenstrual worsening of mood display a worse course of their bipolar illness. Despite this, the neural correlates of comorbid BD and PMDD have not been investigated.MethodologyEighty-five [CTRL, n = 25; PMDD, n = 20; BD, n = 21; BD with comorbid PMDD (BDPMDD), n = 19], regularly cycling women, not on hormonal contraception, underwent two MRI scans: during their mid-follicular and late luteal menstrual phases. We investigated resting-state functional connectivity (Rs-FC), cortical thickness, and subcortical volumes of brain regions associated with the pathophysiology of BD and PMDD between groups, in the mid-follicular and late luteal phases of the menstrual cycle. All BD subjects were euthymic for at least 2 months prior to study entry.ResultsWomen in the BDPMDD group displayed greater disruption in biological rhythms and more subthreshold depressive and anxious symptoms through the menstrual cycle compared to other groups. Rs-FC was increased between the L-hippocampus and R-frontal cortex and decreased between the R-hippocampus and R-premotor cortex in BDPMDD vs. BD (FDR-corrected, p < 0.05). Cortical thickness analysis revealed decreased cortical thickness of the L-pericalcarine, L-superior parietal, R-middle temporal, R-rostral middle frontal, and L-superior frontal, as well as increased cortical thickness of the L-superior temporal gyri in BDPMDD compared to BD. We also found increased left-caudate volume in BDPMDD vs. BD (pCORR < 0.05).ConclusionWomen with BD and comorbid PMDD display a distinct clinical and neurobiological phenotype of BD, which suggests differential sensitivity to endogenous hormones.
Reference Key
syan2018frontiersbrain Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sabrina K. Syan;Sabrina K. Syan;Luciano Minuzzi;Luciano Minuzzi;Luciano Minuzzi;Mara Smith;Dustin Costescu;Olivia R. Allega;Geoffrey B. C. Hall;Benicio N. Frey;Benicio N. Frey;Benicio N. Frey
Journal journal of experimental psychology general
Year 2018
DOI
10.3389/fpsyt.2017.00301
URL
http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00301/full
Keywords
bipolar disorder MRI fmri premenstrual dysphoric disorder

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