efficient synthesis of unprotected c-5-aryl/heteroaryl-2'-deoxyuridine via a suzuki-miyaura reaction in aqueous media

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ID: 162744
2012
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Abstract
Following our previous results on an environmentally benign one-pot Sonogashira-cyclization protocol to obtain substituted furopyrimidine nucleosides under aqueous conditions, we investigate herein the Suzuki-Miyaura cross-coupling reactions of aryl and heteroaryl derivatives at the C5 position of unprotected 2'-deoxyuridine in the same media with a common catalyst system avoiding exotic ligands, since palladium acetate and triphenylphosphine afforded the expected products in moderate to good yields.
Reference Key
fresneau2012moleculesefficient Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Nathalie Fresneau;Marie-Aude Hiebel;Luigi A. Agrofoglio;Sabine Berteina-Raboin
Journal Journal of ethnopharmacology
Year 2012
DOI
10.3390/molecules171214409
URL
http://www.mdpi.com/1420-3049/17/12/14409
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