immunophenotyping of circulating t cells in a mucosal leishmaniasis patient coinfected with hiv
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ID: 162230
2011
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Abstract
HIV coinfection modifies the clinical course of leishmaniasis by promoting a Th2 pattern of cytokine production. However, little information is available regarding the lymphocytic response in untreated coinfected patients. This work presents the immunophenotyping of Leishmania-stimulated T cells from a treatment-naÏve HIV+ patient with ML. Leishmania braziliensis antigens induced CD69 expression on CD3+CD4+ and CD3+CD8+ cells. It also increased IL-4 intracellular staining on CD3+CD4+GATA3- population and decreased the percentage of CD3+CD4+IL-17+ cells. This suggests that modulations in the IL-4R/STAT6 pathway and the Th17 population may serve as parasitic evasion mechanisms in HIV/ML. Further studies are required to confirm these results.
| Reference Key |
castellano2011revistaimmunophenotyping
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|---|---|
| Authors | ;Lúcio Roberto Castellano;Mauricio Llaguno;Marcos Vinícius Silva;Juliana Reis Machado;Dalmo Correia;Mario León Silva-Vergara;Virmondes Rodrigues |
| Journal | mobile information systems |
| Year | 2011 |
| DOI |
10.1590/S0037-86822011000400025
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| URL | |
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