immunotherapy, immunochemotherapy and chemotherapy for american cutaneous leishmaniasis treatment imunoterapia, imunoquimioterapia e quimioterapia no tratamento da leishmaniose tegumentar americana

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ID: 162216
2006
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Abstract
The first choice of treatment for American cutaneous leishmaniasis is the pentavalent antimonial drug. Although it has been shown that this treatment is mostly effective and indicated, some disadvantages should be taken into account such as side effects, long term treatment inconveniences and counter-indication for patients suffering from cardiopathy, nephropathy; yet, aging, pregnancy and other conditions. With the advent of the vaccine anti-American cutaneous leishmaniasis as a prophylactic measure, studies on therapy using the vaccine associated or not with other drugs have been performed by many investigators and it is currently among the alternative treatments and prevention measures for American cutaneous leishmaniasis. In conclusion, the association between antimony and vaccine (immunochemotherapy) showed the same cure rate when compared with the standard treatment (100%) and it was also able to reduce the salt volume in 17.9% and treatment length from 87 to 62 days, decreasing side effects.
O tratamento de primeira escolha para leishmaniose tegumentar americana é o antimonial pentavalente. Embora este tratamento seja na maioria das vezes efetivo e indicado, devem ser consideradas as desvantagens tais como efeitos colaterais, longa duração do tratamento e contra-indicação para cardiopatas, nefropatas, idosos, grávidas e outras condições. Com o advento da vacina antileishmaniose tegumentar americana para fins profiláticos e terapêuticos, associando-a ou não a outros fármacos, muitas pesquisas têm sido desenvolvidas, sendo a vacina a principal entre os atuais recursos no tratamento e prevenção da leishmaniose tegumentar americana. Em conclusão, a associação do antimônio com a vacina (imunoquimioterapia) apresentou o mesmo índice de cura em relação ao tratamento padrão (100%), e ainda reduziu o volume do sal em 17,9% e o tempo de cura significativamente, de 87 para 62 dias; conseqüentemente, reduzindo os efeitos colaterais.
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mayrink2006revistaimmunotherapy, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Wilson Mayrink;Ana Cristina de Carvalho Botelho;Paulo Araújo Magalhães;Sebastião Mariano Batista;Antonio de Oliveira Lima;Odair Genaro;Carlos Alberto da Costa;Maria Norma de Melo;Marilene Susan Marques Michalick;Paul Williams;Magno Dias;Waleska Teixeira Caiaffa;Evaldo do Nascimento;George Luiz Lins Machado-Coelho
Journal mobile information systems
Year 2006
DOI
10.1590/S0037-86822006000100003
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000100003
Keywords
treatment tratamento tropical medicine

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