a facile synthesis of functionalized dispirooxindole derivatives via a three-component 1,3-dipolar cycloaddition reaction
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ID: 162066
2013
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Abstract
An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.
| Reference Key |
ouyang2013moleculesa
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|---|---|
| Authors | ;Liang Ouyang;Rongsheng Tong;Jianyou Shi;Zhixiang Yuan;Guang Ouyang;Jun He |
| Journal | Journal of ethnopharmacology |
| Year | 2013 |
| DOI |
10.3390/molecules18055142
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| URL | |
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