evidence for the role of b cells and immunoglobulins in the pathogenesis of multiple sclerosis

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ID: 161997
2011
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Abstract
The pathogenesis of multiple sclerosis (MS) remains elusive. Recent reports advocate greater involvement of B cells and immunoglobulins in the initiation and propagation of MS lesions at different stages of their ontogeny. The key role of B cells and immunoglobulins in pathogenesis was initially identified by studies in which patients whose fulminant attacks of demyelination did not respond to steroids experienced remarkable functional improvement following plasma exchange. The positive response to Rituximab in Phase II clinical trials of relapsing-remitting MS confirms the role of B cells. The critical question is how B cells contribute to MS. In this paper, we discuss both the deleterious and the beneficial roles of B cells and immunoglobulins in MS lesions. We provide alternative hypotheses to explain both damaging and protective antibody responses.
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wootla2011neurologyevidence Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Bharath Wootla;Aleksandar Denic;B. Mark Keegan;Jeffrey L. Winters;David Astapenko;Arthur E. Warrington;Allan J. Bieber;Moses Rodriguez
Journal Clinical oral investigations
Year 2011
DOI
10.1155/2011/780712
URL
http://dx.doi.org/10.1155/2011/780712
Keywords
neurology diseases of the nervous system

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