nivolumab-induced autoimmune encephalitis in two patients with lung adenocarcinoma

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ID: 161774
2018
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Abstract
Immune checkpoint inhibitors have improved patient survival outcomes in a variety of advanced malignancies. However, they can cause a number of immune-related adverse effects (irAEs) through lymphocyte dysregulation. Central nervous system (CNS) irAEs are rare, but as the number of indications for checkpoint inhibitors increases, there has been emergence of CNS immune-mediated disease among cancer patients. Given the relatively recent recognition of checkpoint inhibitor CNS irAEs, there is no standard treatment, and prognosis is variable. Therefore, there is a great need for further study of checkpoint inhibitor-induced CNS irAEs. Here, we present two unique cases of nivolumab-induced autoimmune encephalitis in patients with non-small cell lung cancer and review the available literature.
Reference Key
shah2018casenivolumab-induced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Suma Shah;Anastasie Dunn-Pirio;Matthew Luedke;Joel Morgenlander;Mark Skeen;Christopher Eckstein
Journal journal of pain research
Year 2018
DOI
10.1155/2018/2548528
URL
http://dx.doi.org/10.1155/2018/2548528
Keywords
neurology diseases of the nervous system

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