a comparison of the antileukaemic effects of recombinant human tumour necrosis factor-α and its muteins on leukaemia l1210 and leukaemia p388 in mice
Clicks: 163
ID: 161771
1994
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Star Article
30.0
/100
163 views
26 readers
AI Quality Assessment
Not analyzed
Readership in this journal
StarRanked #237 of 382 articles by views in polyhedron
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 382 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
We investigated the influence of recombinant human tumour necrosis
factor alpha (TNF-α) and its derivatives termed muteins III, V,
VI—in which the first 3 to 7 amino acids of native TNF-α have been
replaced—on the survival time of mice inoculated with leukaemia
L1210 or leukaemia P338. TNF-α prolonged the survival of mice with
leukaemia L1210 but did not have any therapeutic activity in
leukaemia P388-bearing mice. Muteins-treated mice with leukaemia
P388 lived longer than animals receiving TNF-α, while those
inoculated with leukaemia L1210 did not show any significant
prolongation of life compared with the TNF-α treated group. The
results presented in this report indicate that the antileukaemic
activity of TNF-α is governed at least in part by the nature of the
N-terminal amino acids.
| Reference Key |
warzocha1994mediatorsa
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;K. Warzocha;J. Góra-Tybor;M. Kwinkowski;B. Szymanska;T. Robak |
| Journal | polyhedron |
| Year | 1994 |
| DOI |
10.1155/S0962935194000578
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.