role of t-helper 9 cells in chronic hepatitis c-infected patients
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ID: 161301
2018
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Abstract
Hepatitis C virus is a hepatotropic virus that is transmitted parenterally. Viral infections are usually associated with modulations of the immune cells, leading to enhanced viral survival and spreading, and accordingly, life-threatening complications. Recently, it has been proposed that a new subset of T-helper, named T-helper 9, is involved in the pathogenesis of different immunopathological conditions, such as allergies, tumors, and viral infections. Some studies reported a protective role, and others described a pathogenic potential for the T-helper 9 cells. Here, we present evidence that T-helper 9 cells are dynamically increased with increasing the pathogenic strategy for hepatitis C virus (HCV). Furthermore, viral clearance is associated with a decrease in T-helper 9. The increase in T-helper 9 was paralleled with an increase in its receptor expression. Taken together, our data suggest that T-helper 9 cells play an important role in the pathogenesis of HCV, and is directly associated with HCV-related complications.
| Reference Key |
ali2018virusesrole
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|---|---|
| Authors | ;Mohamed E. Ali;Omnia El-Badawy;Noha A. Afifi;Abeer Sharaf Eldin;Elham Ahmed Hassan;Hamada M. Halby;Mohamed Ahmed El-Mokhtar |
| Journal | International journal of pharmaceutics |
| Year | 2018 |
| DOI |
10.3390/v10070341
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| URL | |
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