a survival association study of 102 polymorphisms previously associated with survival outcomes in colorectal cancer
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2015
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Abstract
Several published studies identified associations
of a number of polymorphisms with a variety of
survival outcomes in colorectal cancer. In this study,
we aimed to explore 102 previously reported common
genetic polymorphisms and their associations with
overall survival (OS) and disease-free survival (DFS)
in a colorectal cancer patient cohort from
Newfoundland n=505. Genotypes were obtained using a
genomewide SNP genotyping platform. For each
polymorphism, the best possible genetic model was
estimated for both overall survival and disease-free survival using a previously published
approach. These SNPs were then analyzed under
their genetic models by Cox regression method.
Correction for multiple comparisons was performed
by the False Discovery Rate (FDR) method.
Univariate analysis results showed that
RRM1-rs12806698,
IFNGR1-rs1327474,
DDX20-rs197412, and
PTGS2-rs5275 polymorphisms were
nominally associated with OS or DFS p<0.01. In stage-adjusted analysis, the
nominal associations of
DDX20-rs197412,
PTGS2-rs5275, and
HSPA5-rs391957 with DFS were
detected. However, after FDR correction none of
these polymorphisms remained significantly
associated with the survival outcomes. We conclude
that polymorphisms investigated in this study are
not associated with OS or DFS in our colorectal
cancer patient cohort.
| Reference Key |
savas2015biomeda
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|---|---|
| Authors | ;Sevtap Savas;Jingxiong Xu;Salem Werdyani;Konstantin Shestopaloff;Elizabeth Dicks;Jane Green;Patrick Parfrey;Roger Green;Wei Xu |
| Journal | spectrochimica acta - part a: molecular and biomolecular spectroscopy |
| Year | 2015 |
| DOI |
10.1155/2015/968743
|
| URL | |
| Keywords |
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