design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus
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2017
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Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.
| Reference Key |
su2017moleculesdesign
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|---|---|
| Authors | ;Jung-Chen Su;Yu-Ting Huang;Chang-Shi Chen;Hao-Chieh Chiu;Chung-Wai Shiau |
| Journal | Journal of ethnopharmacology |
| Year | 2017 |
| DOI |
10.3390/molecules23010027
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| URL | |
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