synthesis and antimicrobial activity of 1-[2-(10-p-chlorobenzyl) phenothiazinyl]-3-(substituted aryl)-2-propen-1-ones

Clicks: 34
ID: 160322
2009
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Abstract
Aiming at the development of antimicrobial agents, we have synthesized nine chlorobenzyl substituted phenothiazinyl chalcones by condensing 2-acetyl phenothiazine with aldehyde derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to Claisen - Schmidt condensation and subsequent reaction of products with p-chlorobenzyl bromide. Structures of these compounds were elucidated by their IR, 'H NMR spectroscopic data and microonalyses. The antimicrobial activity of the new products was evaluated by Filter Paper Disc Method.
Reference Key
upadhyay2009e-journalsynthesis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;R. K. Upadhyay;Megha S. Upadhyay;S. Jain
Journal Journal of pharmaceutical and biomedical analysis
Year 2009
DOI
10.1155/2009/901646
URL
http://dx.doi.org/10.1155/2009/901646
Keywords
chemistry

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