simultaneous determination of gemifloxacin and diuretics in bulk, pharmaceutical dosage forms and human serum by rp-hplc
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ID: 160200
2010
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Abstract
An isocratic reversed phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of gemifloxacin and diuretics (hydrochlorothiazide and furosemide) in bulk, dosage formulations and human serum at 232 nm. Chromatographic separation was achieved on Purospher Start C18 (250 mm x 4.6 mm, 5 µm) column using mobile phase, methanol: water: acetonitrile (70:25:5 v/v/v) adjusted to pH 3.0 via phosphoric acid 85% having flow rate of 0.8 mL min -1 at room temperature. Calibration curves were linear over range of 0.5-10 µg mL -1 with a correlation coefficient ± 0.999. LOD and LOQ were in the ranges of 0.75-2.56 µg mL -1. Intra and inter-run precision and accuracy results were 98.26 to 100.9.
| Reference Key |
sultana2010qumicasimultaneous
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|---|---|
| Authors | ;Najma Sultana;Sana Shamim;Mahwish Akhtarand Somia Gul;M. Saeed Arayne |
| Journal | greece and rome |
| Year | 2010 |
| DOI |
10.1590/S0100-40422010000700029
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