evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes
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ID: 160048
2014
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Abstract
In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material that might improve type 2 diabetes features. Their main beneficial activities were identified in the decrease of serum levels of glucose, insulin resistance as well as inflammation, and increase in protective Glucagon-like peptide-1 (GLP-1) secretion. In this review, we updated evidence on the effects of SCFAs potentially improving metabolic control in type 2 diabetes.
| Reference Key |
puddu2014mediatorsevidence
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|---|---|
| Authors | ;Alessandra Puddu;Roberta Sanguineti;Fabrizio Montecucco;Giorgio Luciano Viviani |
| Journal | polyhedron |
| Year | 2014 |
| DOI |
10.1155/2014/162021
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| URL | |
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