automated analysis of protein expression and gene amplification within the same cells of paraffin-embedded tumour tissue
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2010
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Abstract
Background: The simultaneous detection of protein expression and gene copy number changes in patient samples, like paraffin-embedded tissue sections, is challenging since the procedures of immunohistochemistry (IHC) and Fluorescence in situ Hybridization (FISH) negatively influence each other which often results in suboptimal staining. Therefore, we developed a novel automated algorithm based on relocation which allows subsequent detection of protein content and gene copy number changes within the same cell.
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| Reference Key |
gaiser2010analyticalautomated
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| Authors | ;Timo Gaiser;Lissa Berroa-Garcia;Ralf Kemmerling;Aparajita Dutta;Thomas Ried;Kerstin Heselmeyer-Haddad |
| Journal | oriente moderno |
| Year | 2010 |
| DOI |
10.3233/ACP-CLO-2010-0532
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