synthesis of peptide radiopharmaceuticals for the therapy and diagnosis of tumor diseases
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2013
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Abstract
Despite the advances in molecular biology and biochemistry, the prognosis of patients suffering from tumor diseases remains poor. The limited therapeutic success can be explained by the insufficient performance of the common chemotherapeutic drugs that lack the ability to specifically target tumor tissues. Recently peptide radiopharmaceuticals have been developed that enable the concurrent imaging and therapy of tumors expressing a specific target. Here, with a special emphasis on the synthesis of the building blocks required for the complexation of metallic radioisotopes, the requirements to the design and synthesis of radiolabeled peptides for clinical applications are described.
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| Reference Key |
mier2013moleculessynthesis
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|---|---|
| Authors | ;Walter Mier;Uwe Haberkorn;Mazen Jamous |
| Journal | Journal of ethnopharmacology |
| Year | 2013 |
| DOI |
10.3390/molecules18033379
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| URL | |
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