critical appraisal of cabazitaxel in the management of advanced prostate cancer

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ID: 159762
2010
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Abstract
Sumanta Kumar Pal1, Przemyslaw Twardowski1, Oliver Sartor21Division of Genitourinary Malignancies, Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Los Angeles, CA, USA; 2Departments of Urology and Medicine, Tulane University School of Medicine, New Orleans, LA, USAAbstract: Docetaxel remains a cornerstone of therapy for the patient with metastatic castration-resistant prostate cancer (CRPC). However, the landscape of CRPC therapy is changing rapidly – recently, data from the phase III TROPIC study revealed a survival advantage with the novel taxane cabazitaxel/prednisone (compared with mitoxantrone/prednisone) in a cohort of 755 men with docetaxel-refractory metastatic CRPC. Interestingly, cabazitaxel bears substantial structural similiarity to docetaxel but appears to be mechanistically distinct. In preclinical studies, the agent has antitumor activity in a variety of docetaxel-refractory in vitro and in vivo models. Subsequent to phase I testing in advanced solid tumors (where neutropenia was identified as a dose-limiting toxicity), the agent was assessed in a phase II trial in advanced, taxane-refractory breast cancer and in the aforementioned phase III TROPIC study. This review describes in detail the preclinical and clinical development of cabazitaxel.Keywords: cabazitaxel, castration resistant prostate cancer, Jevtana, breast cancer, taxane
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pal2010clinicalcritical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sumanta Kumar Pal;Przemyslaw Twardowski;Oliver Sartor
Journal imaging science journal
Year 2010
DOI
DOI not found
URL
https://www.dovepress.com/critical-appraisal-of-cabazitaxel-in-the-management-of-advanced-prosta-peer-reviewed-article-CIA
Keywords
Breast cancer cabazitaxel taxanegeriatrics

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