interferon-γ triggers hepatic stellate cell-mediated immune regulation through mek/erk signaling pathway
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2013
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Abstract
Hepatic stellate cells (HSCs) interact with immune cells to actively participate in regulating immune response in the liver which is mediated by the effector molecules, including B7-H1. We demonstrated here that expression of B7-H1 on HSCs was markedly enhanced by interferon-(IFN-) γ stimulation. IFN-γ stimulated HSCs inhibited T-cell proliferation via induction of T-cell apoptosis (22.1% ± 1.6%). This immunosuppressive effect was inhibited by preincubation with an anti-B7-H1 antibody, or inhibitor of the MEK/ERK pathway inhibited IFN-γ mediated expression of B7-H1. Thus, regulation of B7-H1 expression on HSCs by IFN-γ represents an important mechanism that regulates immune responses in the liver favoring tolerogenicity rather than immunogenicity. Involvement of MEK/ERK pathway provides a novel target for therapeutic approaches.
| Reference Key |
gu2013clinicalinterferon-
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|---|---|
| Authors | ;Xiaodong Gu;Yan Wang;Jianbin Xiang;Zongyou Chen;Lianfu Wang;Lina Lu;Shiguang Qian |
| Journal | Applied Surface Science |
| Year | 2013 |
| DOI |
10.1155/2013/389807
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| URL | |
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