human mast cells (hmc-1 5c6) enhance interleukin-6 production by quiescent and lipopolysaccharide-stimulated human coronary artery endothelial cells
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ID: 158627
2012
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Abstract
We examined the effect of intact human mast cells (HMC-1 5C6) and their selected mediators on interleukin-6 (IL-6) production and bone morphogenetic protein-2 (BMP-2) expression in human coronary artery endothelial cells (HCAEC) in the presence and absence of lipopolysaccharide (LPS). Scanning electron microscopy showed that HMC-1 5C6 cells adhere to HCAEC in cocultures. Addition of HMC-1 5C6 cells markedly enhanced the IL-6 production by quiescent and LPS-activated HCAEC even at the maximal concentration of LPS. Furthermore, mast cell-derived histamine and proteases accounted for the direct and synergistic effect of mast cells on IL-6 production that was completely blocked by the combination of histamine receptor-1 antagonist and protease inhibitors. Another novel finding is that histamine was able to induce BMP-2 expression in HCAEC. Collectively, our results suggest that endotoxin and mast cell products synergistically amplify vascular inflammation and that histamine participates in the early events of vascular calcification.
| Reference Key |
walia2012mediatorshuman
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|---|---|
| Authors | ;Damandeep S. Walia;Mukut Sharma;Vineesh V. Raveendran;Jianping Zhou;Ram Sharma;Daniel J. Stechschulte;Kottarappat N. Dileepan |
| Journal | polyhedron |
| Year | 2012 |
| DOI |
10.1155/2012/274347
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| URL | |
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