barrier dysfunction in the skin allergy

Clicks: 243
ID: 158565
2018
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Abstract
The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic diseases such as atopic dermatitis. In this article, we summarize how the physical barrier of the skin is organized and review its link to the pathomechanism of skin allergic diseases. We describe the formation of the SC barrier in terms of the following five categories: 1) filaggrin metabolism; 2) cornified envelope; 3) intercellular lipids; 4) corneodesmosome; and 5) corneocyte desquamation. New approaches to restoring the skin barrier function are also discussed.
Reference Key
egawa2018allergologybarrier Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Gyohei Egawa;Kenji Kabashima
Journal current drug discovery technologies
Year 2018
DOI
10.1016/j.alit.2017.10.002
URL
http://www.sciencedirect.com/science/article/pii/S1323893017301557
Keywords
atopic dermatitis barrier function allergy tight junctionimmunologic diseases

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