the influence of transmitted and non-transmitted parental bmi-associated alleles on the risk of overweight in childhood

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ID: 158009
2020
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Abstract
Abstract Overweight in children is strongly associated with parental body mass index (BMI) and overweight. We assessed parental transmitted and non-transmitted genetic contributions to overweight in children from the Danish National Birth Cohort by constructing genetic risk scores (GRSs) from 941 common genetic variants associated with adult BMI and estimating associations of transmitted maternal/paternal and non-transmitted maternal GRS with child overweight. Maternal and paternal BMI (standard deviation (SD) units) had a strong association with childhood overweight [Odds ratio (OR): 2.01 (95% confidence interval (CI) 1.74; 2.34) and 1.64 (95% CI 1.43; 1.89)]. Maternal and paternal transmitted GRSs (SD-units) increased odds for child overweight equally [OR: 1.30 (95% CI 1.16; 1.46) and 1.30 (95% CI 1.16; 1.47)]. However, both the parental phenotypic and the GRS associations may depend on maternal BMI, being weaker among mothers with overweight. Maternal non-transmitted GRS was not associated with child overweight [OR 0.98 (95% CI 0.88; 1.10)] suggesting no specific influence of maternal adiposity as such. In conclusion, parental transmitted GRSs, based on adult BMI, contribute to child overweight, but in overweight mothers other genetic and environmental factors may play a greater role.
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schnurr2020scientificthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Theresia M. Schnurr;Camilla S. Morgen;Dmitrii Borisevich;Robin N. Beaumont;Line Engelbrechtsen;Lars Ängquist;Christian T. Have;Rachel M. Freathy;George Davey Smith;Ellen A. Nohr;Torben Hansen;Thorkild I. A. Sørensen
Journal historia de la educación
Year 2020
DOI
10.1038/s41598-020-61719-3
URL
http://link.springer.com/article/10.1038/s41598-020-61719-3
Keywords
medicinescience

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