aminolevulinic acid (ala) as a prodrug in photodynamic therapy of cancer

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ID: 157953
2011
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Abstract
Aminolevulinic acid (ALA) is an endogenous metabolite normally formed in the mitochondria from succinyl-CoA and glycine. Conjugation of eight ALA molecules yields protoporphyrin IX (PpIX) and finally leads to formation of heme. Conversion of PpIX to its downstream substrates requires the activity of a rate-limiting enzyme ferrochelatase. When ALA is administered externally the abundantly produced PpIX cannot be quickly converted to its final product - heme by ferrochelatase and therefore accumulates within cells. Since PpIX is a potent photosensitizer this metabolic pathway can be exploited in photodynamic therapy (PDT). This is an already approved therapeutic strategy making ALA one of the most successful prodrugs used in cancer treatment.
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golab2011moleculesaminolevulinic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jakub Golab;Kamil Bojarczuk;Małgorzata Wańczyk;Magdalena Winiarska;Magdalena Gabrysiak;Małgorzata Firczuk;Angelika Muchowicz;Małgorzata Wachowska
Journal Journal of ethnopharmacology
Year 2011
DOI
10.3390/molecules16054140
URL
http://www.mdpi.com/1420-3049/16/5/4140/
Keywords
Cancer 5-aminolevulinic acid photodynamic therapy laser singlet oxygenorganic chemistry

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