targeted drugs as maintenance therapy after autologous stem cell transplantation in patients with mantle cell lymphoma

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ID: 157950
2017
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Abstract
The treatment landscape for mantle cell lymphoma (MCL) is rapidly evolving toward the incorporation of novel and biologically targeted pharmaceuticals with improved disease activity and gentler toxicity profiles compared with conventional chemotherapeutics. Upfront intensive treatment of MCL includes autologous stem cell transplantation (SCT) consolidation aimed at deepening and lengthening disease remission, but subsequent relapse occurs. Maintenance therapy after autologous SCT in patients with MCL in remission features lower-intensity treatments given over extended periods to improve disease outcomes. Targeted drugs are a natural fit for this space, and are the focus of considerable clinical investigation. This review summarizes recent advances in the field and their potential impact on treatment practices for MCL.
Reference Key
yan2017pharmaceuticalstargeted Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Fengting Yan;Ajay K. Gopal;Solomon A. Graf
Journal journal of cerebral blood flow and metabolism
Year 2017
DOI
10.3390/ph10010028
URL
http://www.mdpi.com/1424-8247/10/1/28
Keywords
stem cell transplantation mantle cell lymphoma

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