dysregulation of notch signaling related genes in oral lichen planus

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ID: 157621
2017
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Abstract
Objective: To investigate a dysregulation of Notch signaling in oral lichen planus (OLP) using public available microarray dataset. Methods: A mRNA expression profiling dataset from Gene Expression Omnibus was downloaded. Differential gene expression between OLP and normal oral epithelium was examined using NetworkAnalyst. The dysregulated genes related to Notch signaling were identified. Results: Thirteen genes in Notch signaling pathway were significantly differential expressed between OLP and normal epithelium. OLP samples significantly increased the mRNA levels of HEYL, APH1B, CNTN1 and PSEN2. Whilst, ITCH, HES1, TLE2, DLK2, DTX2, NOTCH3, JAG2, RFNG, and SPEN were downregulated in OLP groups. Conclusions: Notch signaling was dysregulated and may participate in pathophysiologic process in OLP.
Reference Key
nowwarote2017asiandysregulation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Nunthawan Nowwarote;Thanaphum Osathanon
Journal Organic letters
Year 2017
DOI
10.1016/j.apjtb.2017.07.001
URL
http://www.sciencedirect.com/science/article/pii/S2221169117306718
Keywords
notch signaling expression analysis oral lichen planus

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