Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac.

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ID: 1574
2019
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Abstract
The polymorphism of sulindac was investigated by Raman investigations, mainly in the low-wavenumber region in order to analyze the influence of the amorphization method on recrystallization and crystalline form stability. By devitrification of the quenched liquid, it was found that the undercooled liquid crystallizes into Form I, and a polymorphic transformation by cooling Form I toward Form IV, was clearly revealed. The low-wavenumber spectra of polymorphic forms are direct fingerprints of crystals, indicating a degree of disorder of Form IV intermediate between those of the ordered Form II (commercial form) and the relatively disordered Form I. This study has shown the enantiotropic relationship between Forms I and IV and that both the temperature of crystallization and the physical stability of Form I prepared is dependent on the technique used for preparing amorphous sulindac.
Reference Key
latreche2019polymorphism Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Latreche, Mansour;Willart, Jean-François;Paccou, Laurent;Guinet, Yannick;Hédoux, Alain;
Journal International journal of pharmaceutics
Year 2019
DOI
S0378-5173(19)30518-6
URL
Keywords Keywords not found

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