design and synthesis of 5-methylpyrazine-2-carbohydrazide derivatives: a new anti-tubercular scaffold
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ID: 157037
2017
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Abstract
A simple synthetic methodology was employed for synthesis of series of 5-methylpyrazine-2-carbohydrazide derivatives (PM series). In vitro anti-tubercular activity was evaluated against Mycobacterium tuberculosis (H37Rv) in Middle brook 7H-9 broth medium. Amongst synthesized compounds, seven compounds showed remarkable anti-tubercular activity. The 2-D QSAR illustrates the design PM series of compounds as potential anti-tubercular scaffolds that can be further optimized to improve the activity.
| Reference Key |
miniyar2017arabiandesign
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|---|---|
| Authors | ;P.B. Miniyar;S.N. Mokale;S.J. Makhija |
| Journal | Behavioural brain research |
| Year | 2017 |
| DOI |
10.1016/j.arabjc.2013.04.001
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