effect of 0.5g/l cyclosporine a for symptom and sign scores in patients with moderate to severe dry eye
Article Quality & Performance Metrics
Readership in this journal
SteadyRanked #104 of 133 articles by views in journal of fungi
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 133 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
Abstract
METHODS:Eighty patients(160 eyes)with moderate to severe dry eye were divided into two groups by double-blind and random principles:40 patients(80 eyes)in observation group were treated with 10g/L sodium carboxymethyl cellulose and 0.5g/L cyclosporine A eye drops, 40 patients(80 eyes)in the control group were treated with 10g/L sodium carboxymethyl cellulose eye drops. The changes of ocular sign and symptom scores were compared between the two groups.
RESULTS:The total effective rate of observation group was 95.0%, which was significantly higher than that of control group(85.0%, P<0.05). Symptom scores before treatment in observation group and the control group were 36.1±4.4 and 36.4±4.5 points, respectively; symptom scores at 1 and 3mo after treatment were 25.2±3.2, 11.09±3.9 points in observation group, 29.4±4.1, 22.05±3.1 points in control group. The differences of the two groups before and after treatment were statistically significantly(P<0.05). The scores of observation group at 1 and 3mo after treatment were lower than those of control group(P<0.05). Before treatment, break-up time(BUT), Schirmer I test(SⅠt), fluorescein staining(FL)and ocular surface disease index(OSDI)scores had no significant differences between the two groups(P>0.05). After treatment, the four parameters of observation group were improved significantly(P<0.05), while only FL and OSDI of control group were improved(P<0.05). The four parameters of observation group were higher than those of control group(P<0.05).Three eyes in observation group felt tingling during 14-28d of the drug using, 2 eyes in control group felt tingling and one eye in control group had conjunctival congestion. All the symptoms disappeared after 2d without stopping the drugs.
CONCLUSION:The 0.5g/L cyclosporine A eye drops can effectively relieve the symptoms and signs of moderate to severe dry eye, promote tear secretion, and improve ocular surface environment. The treatment effect is good.
| Reference Key |
yu2016guojieffect
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Su-Ying Yu;Cheng-Rong Fu |
| Journal | journal of fungi |
| Year | 2016 |
| DOI |
10.3980/j.issn.1672-5123.2016.5.32
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.