learning-facilitated synaptic plasticity occurs in the intermediate hippocampus in association with spatial learning
Clicks: 308
ID: 156870
2013
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
308 views
52 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #25 of 50 articles by views in Diabetes
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
The dorsoventral axis of the hippocampus is differentiated into dorsal, intermediate and ventral parts. Whereas the dorsal part is believed to specialize in processing spatial information, the ventral may be equipped to process non-spatial information. The precise role of the intermediate hippocampus is unclear, although recent data suggests it is functionally distinct, at least from the dorsal hippocampus. Learning-facilitated synaptic plasticity describes the ability of hippocampal synapses to respond with robust synaptic plasticity (>24h) when a spatial learning event is coupled with afferent stimulation that would normally not lead to a lasting plasticity response: In the dorsal hippocampus novel space facilitates robust expression of LTP, whereas novel spatial content facilitates LTD. We explored whether the intermediate hippocampus engages in this kind of synaptic plasticity in response to novel spatial experience.In freely moving rats, high-frequency stimulation at 200Hz (3 bursts of 15 stimuli) elicited synaptic potentiation that lasted for at least 4h. Coupling of this stimulation with the exploration of a novel holeboard resulted in long-term potentiation (LTP) that lasted for over 24h. Low frequency afferent stimulation (1Hz, 900 pulses) resulted in short-term depression (STD) that was significantly enhanced and prolonged by exposure to a novel large orientational (landmark) cues, however LTD was not enabled. Exposure to a holeboard that included novel objects in the holeboard holes elicited a transient enhancement of STD of the population spike but not field EPSP, and also failed to facilitate the expression of LTD. Our data suggest that the intermediate dentate gyrus engages in processing of spatial information, but is functionally distinct to the dorsal dentate gyrus. This may in turn reflect their assumed different roles in synaptic information processing and memory formation.
| Reference Key |
ekenney2013frontierslearning-facilitated
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Jana eKenney;Denise eManahan-Vaughan |
| Journal | Diabetes |
| Year | 2013 |
| DOI |
10.3389/fnsyn.2013.00010
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.