evaluation of epstein-barr virus latent membrane protein 2 specific t-cell receptors driven by t-cell specific promoters using lentiviral vector
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ID: 156728
2011
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Abstract
Transduction of latent membrane protein 2 (LMP2)-specific T-cell receptors into activated T lymphocytes may provide a universal, MHC-restricted mean to treat EBV-associated tumors in adoptive immunotherapy. We compared TCR-specific promoters of distinct origin in lentiviral vectors, that is, Vβ6.7, delta, luria, and Vβ5.1 to evaluate TCR gene expression in human primary peripheral blood monocytes and T cell line HSB2. Vectors containing Vβ 6.7 promoter were found to be optimal for expression in PBMCs, and they maintained expression of the transduced TCRs for up to 7 weeks. These cells had the potential to recognize subdominant EBV latency antigens as measured by cytotoxicity and IFN-γ secretion. The nude mice also exhibited significant resistance to the HLA-A2 and LMP2-positive CNE tumor cell challenge after being infused with lentiviral transduced CTLs. In conclusion, LMP2-specific CTLs by lentiviral transduction have the potential use for treatment of EBV-related tumors.
| Reference Key |
yang2011clinicalevaluation
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| Authors | ;Dongchang Yang;Qing Shao;Hua Sun;Xiaoxin Mu;Yun Gao;Runqiu Jiang;Jiajie Hou;Kun Yao;Yun Chen;Beicheng Sun |
| Journal | Applied Surface Science |
| Year | 2011 |
| DOI |
10.1155/2011/716926
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