risk assessment for sudden death in epilepsy: the sudep-7 inventory
Clicks: 340
ID: 156403
2015
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
340 views
37 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #35 of 263 articles by views in journal of photochemistry and photobiology a: chemistry
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 263 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a major cause of death in those with drug resistant epilepsy. There is a need for inventories and biomarkers associated with the risk for SUDEP. Objective: To explore the revised SUDEP Risk Inventory (SUDEP-7) in a cohort with Drug Resistant Epilepsy, and determine the association with Heart Rate and other covariates. Methods: 25 subjects with severe drug-resistant epilepsy were enrolled in a clinical trial for epilepsy. Baseline demographics, duration of epilepsy, seizure types, seizure frequency, seizure severity, AED’s, and vital signs were collected. Heart rate variability (HRV) was calculated from 1-hour recordings of ECG. A SUDEP Risk Inventory (SUDEP-7) was administered, which included 7 validated and weighted risk factors initially identified by Walczak et al. as factors associated with SUDEP risk.Results: The total score on the revised SUDEP-7 ranged from 1 to 7, mean = 3.4 (sd 1.8). The SUDEP Risk Inventory score was inversely correlated with RMSSD (Pearson r= -0.45, P=0.027). The following variables were significantly associated with RMSSD: epilepsy duration (p=0.02), age (p=0.03), and developmental intellectual disability (p<0.001). The correlation between RMSSD and SUDEP 7 tended to persist also after the adjustment for patient age (r = -0.40, p=0.05). Two subjects died of SUDEP: their SUDEP-7 scores were above average and in the upper 25 and 50th percentiles respectively (6 and 4, mean = 3.4)Conclusions: RMSSD, a measure of low frequency heart rate variability, was significantly associated with SUDEP Risk Inventory (SUDEP-7) scores. Using a multivariable model, the covariates of developmental intellectual disability, age, and duration of epilepsy were also significantly associated with decreased HRV. The correlation between decreased HRV and a higher SUDEP-7 score remained unchanged even after the adjustment for patient age. The results suggest that older age, greater duration of epilepsy and the presence of developmental intellectual disability may increase the risk of SUDEP through their direct influence on decreasing the vagus nerve mediated HRV.
| Reference Key |
novak2015frontiersrisk
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Jennifer L Novak;Patrick R Miller;Daniela eMarkovic;Sheba eMeyandi;Christopher Michael DeGiorgio |
| Journal | journal of photochemistry and photobiology a: chemistry |
| Year | 2015 |
| DOI |
10.3389/fneur.2015.00252
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.