myocardial perfusion and function are distinctly altered by sevoflurane anesthesia in diet-induced prediabetic rats

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ID: 156380
2016
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Abstract
Preservation of myocardial perfusion during surgery is particularly important in patients with increased risk for perioperative complications, such as diabetes. Volatile anesthetics, like sevoflurane, have cardiodepressive effects and may aggravate cardiovascular complications. We investigated the effect of sevoflurane on myocardial perfusion and function in prediabetic rats. Rats were fed a western diet (WD; n=18) or control diet (CD; n=18) for 8 weeks and underwent (contrast) echocardiography to determine perfusion and function during baseline and sevoflurane exposure. Myocardial perfusion was estimated based on the product of microvascular filling velocity and blood volume. WD-feeding resulted in a prediabetic phenotype characterized by obesity, hyperinsulinemia, hyperlipidemia, glucose intolerance, and hyperglycemia. At baseline, WD-feeding impaired myocardial perfusion and systolic function compared to CD-feeding. Exposure of healthy rats to sevoflurane increased the microvascular filling velocity without altering myocardial perfusion but impaired systolic function. In prediabetic rats, sevoflurane did also not affect myocardial perfusion; however, it further impaired systolic function. Diet-induced prediabetes is associated with impaired myocardial perfusion and function in rats. While sevoflurane further impaired systolic function, it did not affect myocardial perfusion in prediabetic rats. Our findings suggest that sevoflurane anesthesia leads to uncoupling of myocardial perfusion and function, irrespective of the metabolic state.
Reference Key
brom2016journalmyocardial Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Charissa E. van den Brom;Chantal A. Boly;Carolien S. E. Bulte;Rob F. P. van den Akker;Rick F. J. Kwekkeboom;Stephan A. Loer;Christa Boer;R. Arthur Bouwman
Journal applied computer science
Year 2016
DOI
10.1155/2016/5205631
URL
http://dx.doi.org/10.1155/2016/5205631
Keywords
clinical endocrinology diseases of the endocrine glands

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